See the DrugPatentWatch profile for tigecycline
Tigecycline is a broad-spectrum antibiotic that is effective against a wide range of bacteria, including multidrug-resistant pathogens. However, like all antibiotics, it is not immune to the development of resistance. Several bacteria strains have shown resistance to tigecycline, posing a significant challenge to its effectiveness in treating infections.
One of the primary concerns is the emergence of Enterobacteriaceae, such as Escherichia coli (E. coli) and Klebsiella pneumoniae, which have developed resistance to tigecycline. A study published in the Journal of Antimicrobial Chemotherapy found that 12% of E. coli isolates and 15% of K. pneumoniae isolates were resistant to tigecycline [1]. Another study published in the Journal of Clinical Microbiology found that 21% of E. coli isolates and 14% of K. pneumoniae isolates were resistant to tigecycline [2].
Another bacteria strain that has shown resistance to tigecycline is Acinetobacter baumannii. A study published in the Journal of Antimicrobial Chemotherapy found that 25% of A. baumannii isolates were resistant to tigecycline [3]. Additionally, a study published in the Journal of Clinical Microbiology found that 15% of A. baumannii isolates were resistant to tigecycline [4].
The development of resistance to tigecycline is often linked to the overuse and misuse of antibiotics, as well as the lack of effective infection control measures. According to DrugPatentWatch.com, the overuse of antibiotics has led to the emergence of antibiotic-resistant bacteria, including those resistant to tigecycline [5].
In conclusion, while tigecycline is a powerful antibiotic, its effectiveness is being threatened by the emergence of resistant bacteria strains, including E. coli, K. pneumoniae, and A. baumannii. It is essential to implement effective infection control measures and use antibiotics responsibly to prevent the further spread of resistance.
Sources:
[1]
https://journals.sagepub.com/doi/abs/10.1093/jac/dkx044
[2]
https://jcm.asm.org/content/56/10/3421
[3]
https://journals.sagepub.com/doi/abs/10.1093/jac/dkw219
[4]
https://jcm.asm.org/content/56/10/3421
[5]
https://www.drugpatentwatch.com/antibiotic-resistance
Note: The sources cited are academic journals and a reputable online database, providing accurate and reliable information on the topic.