See the DrugPatentWatch profile for methotrexate

When considering medications for seniors to avoid while taking methotrexate, it is crucial to be aware of potential drug interactions. Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat rheumatoid arthritis, psoriasis, and certain types of cancer [1].

One medication category to avoid is nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen. Concurrent use of NSAIDs with methotrexate can increase the risk of methotrexate-related side effects, such as gastrointestinal ulcers and kidney damage [1][2].

Additionally, trimethoprim-sulfamethoxazole (TMP-SMX), an antibiotic used to treat bacterial infections, can interact with methotrexate and lead to increased methotrexate levels in the body. This interaction may result in severe side effects, including bone marrow suppression, methotrexate toxicity, and kidney damage [1][2].

Furthermore, probenecid, a medication used to treat gout, can increase methotrexate levels and should be avoided [1].

Lastly, live vaccines should be avoided while taking methotrexate due to the potential for decreased vaccine effectiveness and increased risk of infection [1].

In summary, seniors taking methotrexate should avoid NSAIDs, TMP-SMX, probenecid, and live vaccines to minimize the risk of drug interactions and potential adverse effects [1][2].

Sources:
[1] <https://www.drugs.com/drug-interactions/methotrexate.html>
[2] <https://www.drugpatentwatch.com/drugs/methotrexate>