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To avoid grapefruit interactions with Lipitor, a medication used to treat high cholesterol, it is recommended to avoid consuming grapefruit or grapefruit juice [1]. The interaction between Lipitor (atorvastatin) and grapefruit can result in increased levels of the drug in the body, which may increase the risk of side effects and adverse reactions [1].

The active compounds in grapefruit, known as furanocoumarins, can inhibit an enzyme in the small intestine called CYP3A4, which is responsible for metabolizing Lipitor [1]. When this enzyme is inhibited, the absorption of Lipitor increases, leading to higher levels of the drug in the bloodstream [1].

It is important to note that the interaction between Lipitor and grapefruit can occur even if the grapefruit is consumed several hours before or after taking the medication [1]. Therefore, it is recommended to avoid consuming grapefruit or grapefruit juice altogether while taking Lipitor [1].

If you have any concerns or questions about grapefruit interactions with Lipitor, it is recommended to speak with your healthcare provider or pharmacist [1]. They can provide you with personalized advice based on your medical history and current medications [1].

In summary, to avoid grapefruit interactions with Lipitor, it is recommended to avoid consuming grapefruit or grapefruit juice [1]. The interaction between Lipitor and grapefruit can result in increased levels of the drug in the body, which may increase the risk of side effects and adverse reactions [1].

Sources:

1. DrugPatentWatch.com. (n.d.). Grapefruit and Lipitor (Atorvastatin) Interaction. Retrieved from <https://www.drugpatentwatch.com/drugs/grapefruit-and-lipitor-atorvastatin-interaction>.