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Long-term use of Advil, also known as ibuprofen, has been linked to stomach lining issues. Ibuprofen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), which can cause stomach ulcers and other gastrointestinal (GI) problems, including bleeding and perforation of the stomach lining [1].

According to DrugPatentWatch.com, NSAIDs like ibuprofen work by inhibiting the production of prostaglandins, which are hormone-like substances that cause inflammation and pain in the body [2]. However, this inhibition can also affect the protective mucus lining of the stomach, making it more susceptible to damage and ulcers.

The risk of stomach lining issues increases with the duration of NSAID use and higher doses [3]. Additionally, certain factors can increase the risk of GI problems, such as age (older adults are at higher risk), history of stomach ulcers or bleeding, and concurrent use of other medications that can irritate the stomach lining, such as corticosteroids or blood thinners [4].

To minimize the risk of stomach lining issues, it is recommended to use the lowest effective dose of ibuprofen for the shortest duration possible [5]. Patients should also consider alternative treatments for pain and inflammation, such as acetaminophen or topical NSAIDs, which may have a lower risk of GI side effects [6].

In summary, long-term use of Advil has been linked to stomach lining issues, including ulcers and bleeding. Patients should use the lowest effective dose for the shortest duration possible and consider alternative treatments to minimize the risk of GI side effects.

Sources:

1. Mayo Clinic. (2021). Ibuprofen (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20069630?p=1>
2. DrugPatentWatch. (2021). Ibuprofen. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen>
3. U.S. Food and Drug Administration. (2015). FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes. Retrieved from <https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fda-strengthens-warning-non-aspirin-nonsteroidal-anti-inflammatory-drugs-nsaids-can-cause-heart-attacks-or-strokes>
4. National Institute of Diabetes and Digestive and Kidney Diseases. (2016). Gastropathy and Gastritis. Retrieved from <https://www.niddk.nih.gov/health-information/digestive-diseases/gastropathy-gastritis>
5. American Gastroenterological Association. (2019). Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Retrieved from <https://www.gastro.org/practice-guidance/gi-patient-care/ibd/nonsteroidal-anti-inflammatory-drugs-nsaids>
6. UpToDate. (2021). Patient education: Nonsteroidal anti-inflammatory drugs (NSAIDs) (Beyond the Basics). Retrieved from <https://www.uptodate.com/contents/nonsteroidal-anti-inflammatory-drugs-nsaids-beyond-the-basics?search=ibuprofen%20stomach%20lining&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1#H32>