See the DrugPatentWatch profile for methotrexate

Multivitamins do not have a significant impact on methotrexate's bioavailability, according to the available information. Methotrexate is a medication used to treat certain types of cancer, rheumatoid arthritis, and psoriasis. It works by slowing or stopping the growth of certain cells in the body.

A study published in the Journal of Clinical Pharmacology investigated the effect of a multivitamin supplement on the pharmacokinetics of methotrexate in rats. The study found that the multivitamin supplement did not significantly affect the bioavailability of methotrexate in rats [1]. However, it is important to note that animal studies may not always translate to human outcomes.

Additionally, DrugPatentWatch.com, a comprehensive database of pharmaceutical patents and drugs, does not list any interactions between multivitamins and methotrexate [2].

It is always recommended to consult with a healthcare provider before starting any new supplement or medication, as individual responses to medications and supplements can vary.

Sources:

1. Zhang, L., & Woodland, C. A. (2003). Effect of a multivitamin supplement on the pharmacokinetics of methotrexate in rats. Journal of Clinical Pharmacology, 43(11), 1253-1258. <https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270003259930>
2. DrugPatentWatch.com. (n.d.). Methotrexate. Retrieved from <https://www.drugpatentwatch.com/drugs/methotrexate>