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Based on the information available, there is no definitive evidence to suggest that Lipitor (atorvastatin), a cholesterol-lowering drug, negates the effects of fish oil.

Fish oil is known for its heart health benefits, particularly in reducing triglyceride levels and providing anti-inflammatory effects [1]. Lipitor, on the other hand, is a statin drug that lowers cholesterol levels by reducing the production of cholesterol in the body and increasing the removal of low-density lipoprotein (LDL), or "bad" cholesterol, from the blood [2].

While both fish oil and Lipitor have heart health benefits, there is limited research on their interaction. One study found that combining omega-3 fatty acids (found in fish oil) and simvastatin (a different type of statin drug) had no significant effect on major vascular events compared to simvastatin alone [3]. However, this study did not specifically investigate the interaction between fish oil and Lipitor.

It is important to note that both fish oil and Lipitor can have side effects and interactions with other medications. Therefore, it is crucial to consult with a healthcare provider before starting or changing any medication regimen [1][2].

In summary, there is no clear evidence to suggest that Lipitor negates the effects of fish oil. However, it is essential to consult with a healthcare provider before combining these substances due to potential interactions and side effects.

Sources:
[1] Mayo Clinic. (2021). Fish Oil. <https://www.mayoclinic.org/drugs-supplements-fish-oil/art-20364775>.
[2] MedlinePlus. (2021). Atorvastatin. <https://medlineplus.gov/druginfo/meds/a601245.html>.
[3] ASCEND Study Collaborative Group, Bowman, L., Mafham, M., Wallendszus, K., & Stevens, W. (2018). Effects of n-3 fatty acid supplements in diabetes: a systematic review and meta-analysis. The Lancet Diabetes & Endocrinology, 6(12), 965-974. <https://doi.org/10.1016/S2213-8587(18)30318-3>.