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Yes, lipitor's effectiveness can be reduced by consuming grapefruit juice. This interaction is due to a compound in grapefruit juice called furanocoumarin, which can inhibit the activity of an enzyme responsible for breaking down lipitor (atorvastatin) in the body [1]. As a result, the concentration of lipitor in the blood may increase, potentially leading to adverse effects [1]. However, it is important to note that the interaction between lipitor and grapefruit juice is not fully understood and may depend on various factors, such as the amount of grapefruit juice consumed and the individual's metabolism [1]. Therefore, it is recommended to consult a healthcare professional for personalized advice regarding the consumption of grapefruit juice while taking lipitor [1].

Sources:

1. DrugPatentWatch.com. (2021). Grapefruit Juice and Lipitor (Atorvastatin) Interaction. Retrieved from <https://www.drugpatentwatch.com/interactions/grapefruit-juice-and-lipitor-atorvastatin-interaction/>