See the DrugPatentWatch profile for lurbinectedin

There is limited research and information available on the direct interaction between acupuncture and lurbinectedin's pathways for nausea. However, we can examine the effects of acupuncture on nausea in general and the mechanism of action of lurbinectedin.

Acupuncture is a traditional Chinese medicine practice that involves the insertion of thin needles into specific points on the body. It has been used to alleviate various symptoms, including nausea [1]. According to some studies, acupuncture may help reduce nausea by stimulating the release of neurotransmitters, such as serotonin, dopamine, and noradrenaline, which can influence the vomiting center in the brainstem [2].

Lurbinectedin is an antineoplastic agent used to treat small cell lung cancer. One of its common side effects is nausea [3]. Lurbinectedin's mechanism of action involves binding to DNA and inhibiting transcription, which can lead to tumor cell death [4]. However, the drug's interaction with nausea pathways is not well understood.

There is no direct evidence on how acupuncture affects lurbinectedin's nausea pathways. Nonetheless, acupuncture can be considered a complementary therapy to manage nausea in cancer patients undergoing treatment with lurbinectedin or other antineoplastic agents. It is crucial to consult healthcare professionals for personalized treatment plans and guidance.

Sources:

1. "Acupuncture." Mayo Clinic, Mayo Foundation for Medical Education and Research, 15 Jan. 2021, [www.mayoclinic.org/tests-procedures/acupuncture/about/pac-20392765](http://www.mayoclinic.org/tests-procedures/acupuncture/about/pac-20392765).
2. "Acupuncture-Point Stimulation for Symptom Management: Opioid-Sparing and Other Potential Mechanisms of Action." National Center for Complementary and Integrative Health, U.S. Department of Health and Human Services, 15 Nov. 2018, [www.nccih.nih.gov/research/acupuncture-point-stimulation-for-symptom-management-opioid-sparing-and-other-potential-mechanisms-of-action](http://www.nccih.nih.gov/research/acupuncture-point-stimulation-for-symptom-management-opioid-sparing-and-other-potential-mechanisms-of-action).
3. "Lurbinectedin." Drugs.com, [www.drugs.com/mtm/lurbinectedin.html](http://www.drugs.com/mtm/lurbinectedin.html).
4. "Lurbinectedin." DrugPatentWatch.com, [www.drugpatentwatch.com/drugs/lurbinectedin](http://www.drugpatentwatch.com/drugs/lurbinectedin).