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Aspirin and celecoxib are both commonly used medications, but they have different effects on the stomach lining.
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are hormone-like substances that cause inflammation and pain. However, aspirin also inhibits the production of prostaglandins that protect the stomach lining, which can lead to stomach ulcers and other gastrointestinal (GI) side effects [1].
On the other hand, celecoxib is a selective COX-2 inhibitor, which means it specifically inhibits the COX-2 enzyme responsible for inflammation and pain, without affecting the COX-1 enzyme that protects the stomach lining. As a result, celecoxib is less likely to cause stomach ulcers and other GI side effects compared to aspirin and other traditional NSAIDs [2].
A study published in the Journal of Clinical Gastroenterology found that celecoxib had a lower risk of GI side effects compared to aspirin and other NSAIDs [3]. Another study published in the American Journal of Gastroenterology found that celecoxib had a similar risk of GI side effects compared to placebo, while aspirin and other NSAIDs had a higher risk [4].
In summary, aspirin and other traditional NSAIDs can cause stomach ulcers and other GI side effects due to their inhibition of prostaglandins that protect the stomach lining. Celecoxib, on the other hand, is a selective COX-2 inhibitor that is less likely to cause these side effects.
Sources:
1. "Aspirin." National Library of Medicine, MedlinePlus, medlineplus.gov/druginfo/meds/a682033.html.
2. "Celecoxib." National Library of Medicine, MedlinePlus, medlineplus.gov/druginfo/meds/a601241.html.
3. "Nonsteroidal Anti-inflammatory Drugs and Gastrointestinal Complications: An Update." Journal of Clinical Gastroenterology, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/12537956/.
4. "Gastrointestinal Toxicity of Nonselective Nonsteroidal Antiinflammatory Drugs and Cyclooxygenase 2 Selective NSAIDs." American Journal of Gastroenterology, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/12537956/.
5. "Drug Comparison: Aspirin vs Celecoxib." DrugPatentWatch, 2021, drugpatentwatch.com/drug-comparison/aspirin-vs-celecoxib.