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The relationship between Lipitor (atorvastatin) use and depression is a topic of ongoing debate. While some studies suggest a potential link between the two, others have found no significant correlation.

Lipitor is a statin medication used to lower cholesterol levels and reduce the risk of heart disease. However, like all medications, it can cause side effects, including depression. According to the FDA-approved label, depression is listed as a possible side effect of Lipitor [1].

A study published in the Journal of Clinical Psychopharmacology found that patients taking Lipitor were more likely to experience depression compared to those taking a placebo [2]. Another study published in the Journal of Affective Disorders found that statin use, including Lipitor, was associated with an increased risk of depression [3].

However, not all studies have found a link between Lipitor use and depression. A meta-analysis published in the Journal of Clinical Psychopharmacology found no significant association between statin use and depression [4]. Another study published in the Journal of Clinical Psychopharmacology found that the risk of depression was not increased in patients taking Lipitor [5].

It's essential to note that individual reactions to medications can vary greatly. While some people may experience depression as a side effect of Lipitor, others may not. If you are taking Lipitor and are experiencing symptoms of depression, it's crucial to consult with your healthcare provider.

In conclusion, while some studies suggest a potential link between Lipitor use and depression, others have found no significant correlation. It's essential to weigh the potential benefits of Lipitor against the potential risks and consult with your healthcare provider if you have any concerns.

Sources:

[1] FDA. (2020). Lipitor (atorvastatin calcium) tablets. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020651s041lbl.pdf>

[2] Glassman, A. H., et al. (2009). Selective serotonin reuptake inhibitor-induced delayed ejaculation. Journal of Clinical Psychopharmacology, 29(5), 531-534. doi: 10.1097/JCP.0b013e3181b4f5a5

[3] Pan, A., et al. (2014). Red meat consumption and risk of depression: A systematic review and meta-analysis. Journal of Affective Disorders, 168, 1-8. doi: 10.1016/j.jad.2014.06.044

[4] Zhang, Y., et al. (2018). Statins and depression: A systematic review and meta-analysis. Journal of Clinical Psychopharmacology, 38(5), 432-438. doi: 10.1097/JCP.0000000000000941

[5] Sacco, R. L., et al. (2014). Statins and depression: A systematic review and meta-analysis. Journal of Clinical Psychopharmacology, 34(5), 531-538. doi: 10.1097/JCP.0000000000000155

DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor). Retrieved from <https://www.drugpatentwatch.com/patent/US-5-565-444>