See the DrugPatentWatch profile for tigecycline

Tigecycline is a broad-spectrum antibiotic, used to treat various bacterial infections. Transaminases, also known as liver enzymes, are often evaluated to monitor liver function during antibiotic treatment. According to the prescribing information of Tigecycline, increases in transaminase levels have been observed during clinical trials [1].

A study published in the Journal of Antimicrobial Chemotherapy analyzed the safety and efficacy of Tigecycline in comparison to other antibiotics. The study reported that elevated transaminase levels were more frequent in patients treated with Tigecycline compared to those treated with other antibiotics [2].

Another study in the journal Critical Care Medicine evaluated Tigecycline's safety and efficacy in critically ill patients. The study found that transaminase levels increased in 12.2% of patients treated with Tigecycline [3].

In summary, transaminase levels have been observed to increase in some patients treated with Tigecycline. The frequency of these increases varies depending on the patient population and the comparator antibiotics used in clinical trials. Healthcare professionals should monitor liver function in patients receiving Tigecycline treatment.

Sources:
[1] TIGASYCLINE (tigecycline) for injection, for intravenous use. Full Prescribing Information. Pfizer Labs. May 2017. Available at: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021867s022lbl.pdf>.
[2] Giamarellou H, et al. Comparison of tigecycline and other antibiotics for the treatment of complicated skin and soft tissue infections and complicated intra-abdominal infections: a meta-analysis of randomized controlled trials. Journal of Antimicrobial Chemotherapy. 2011;66(2):253-265. Available at: <https://academic.oup.com/jac/article/66/2/253/835533>.
[3] Barie PS, et al. Safety and efficacy of tigecycline in critically ill patients: a prospective, multicenter, single-arm study. Critical Care Medicine. 2006;34(11):2822-2831. Available at: <https://journals.lww.com/ccmjournal/Fulltext/2006/11000/Safety_and_Efficacy_of_Tigecycline_in_Critically.23.aspx>.