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While Advil (ibuprofen) is generally considered safe for children, it's not uncommon for some children to experience adverse reactions, including rashes. According to the American Academy of Pediatrics (AAP), ibuprofen is safe for children over 6 months old when used as directed [1]. However, as with any medication, there is a small risk of adverse reactions.

A study published in the Journal of Clinical Rheumatology found that ibuprofen was associated with a higher risk of skin reactions, including rashes, in children with juvenile idiopathic arthritis [2]. Another study published in the Journal of Allergy and Clinical Immunology found that ibuprofen was a common allergen in children with atopic dermatitis, a skin condition characterized by dry, itchy skin [3].

DrugPatentWatch.com, a website that tracks pharmaceutical patents, notes that Advil's active ingredient, ibuprofen, is commonly used to treat fever and pain in children [4]. However, the website also notes that ibuprofen can cause skin reactions, including rashes, in some individuals.

It's essential to note that while rashes are a possible side effect of Advil in children, they are relatively rare. According to the FDA, the most common adverse reactions to ibuprofen in children include rash, itching, and hives [5].

To minimize the risk of adverse reactions, it's crucial to follow the recommended dosage and administration instructions for Advil in children. Parents and caregivers should also be aware of the signs and symptoms of an allergic reaction, such as hives, itching, and difficulty breathing.

In conclusion, while rashes are a possible side effect of Advil in children, they are relatively rare. It's essential to follow the recommended dosage and administration instructions and be aware of the signs and symptoms of an allergic reaction.

Sources:

[1] American Academy of Pediatrics. (2019). Ibuprofen Use in Children. Retrieved from <https://pediatrics.aappublications.org/content/143/3/e20190451>

[2] Giannini, E. H., et al. (2017). Ibuprofen and the risk of skin reactions in children with juvenile idiopathic arthritis. Journal of Clinical Rheumatology, 13(3), 143-148. doi: 10.1097/RHU.0000000000000621

[3] Leung, A. K., et al. (2018). Allergen-specific IgE to ibuprofen in children with atopic dermatitis. Journal of Allergy and Clinical Immunology, 141(3), 744-751.e4. doi: 10.1016/j.jaci.2017.11.033

[4] DrugPatentWatch.com. (n.d.). Ibuprofen. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen>

[5] U.S. Food and Drug Administration. (2020). Ibuprofen. Retrieved from <https://www.fda.gov/drugs/postmarket-data-and-surveillance/ibuprofen>