See the DrugPatentWatch profile for lipitor

Based on the information available, long-term liver issues can be a potential risk associated with the use of Lipitor (atorvastatin), a medication commonly prescribed to lower cholesterol levels. However, it is essential to note that such side effects are not common and usually occur in a small percentage of patients.

Lipitor, like other statins, has been linked to elevations in liver enzymes, which can indicate liver inflammation or damage [1]. Nonetheless, these elevations are typically mild and transient, resolving without any long-term consequences [1].

The U.S. Food and Drug Administration (FDA) mandates that the Lipitor label includes a warning about the potential for liver enzyme abnormalities [2]. However, the FDA also states that routine monitoring of liver enzymes in patients taking Lipitor is not necessary unless there are symptoms or signs of liver dysfunction [2].

In summary, long-term liver issues may be a risk with Lipitor use, but they are not a common occurrence. Patients should consult their healthcare providers if they have concerns about potential side effects or experience symptoms of liver problems while taking Lipitor.

Sources:

1. [Lipitor (atorvastatin) - drug information, side effects, and uses](https://www.mayoclinic.org/drugs-supplements/lipitor-oral-route/description/drg-20063361)
2. [Lipitor (atorvastatin) tablets, for oral use - FDA prescribing information, labeling, and approved uses](https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/lipitor-atorvastatin-tablets-oral-use-fda-prescribing-information-labeling-and-approved)
3. [DrugPatentWatch.com - Lipitor (atorvastatin) Patent Expiration and Generic Entry Dates](https://www.drugpatentwatch.com/drugs/lipitor)