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When it comes to taking Benadryl (diphenhydramine) while on Lipitor (atorvastatin), it is essential to consider several factors before determining the recommended dosage. These factors include the patient's age, weight, overall health, and the specific medical conditions being treated [1]. However, it is crucial to note that there is no specific recommended dosage for Benadryl use with Lipitor, as these medications are typically used to treat different symptoms and conditions [1].

Benadryl is an antihistamine medication commonly used to treat allergies, while Lipitor is a statin drug prescribed to lower cholesterol levels [1][2]. Although both medications can be taken together, it is essential to consult a healthcare professional before combining them, as they can interact and potentially cause side effects [1].

When taking Benadryl and Lipitor together, it is crucial to follow the recommended dosage for each medication individually, as directed by a healthcare professional or pharmacist [1]. For Benadryl, the typical dosage for adults and children 12 years and older is 25 to 50 mg every 4 to 6 hours, not to exceed 300 mg in 24 hours [1]. For Lipitor, the usual starting dosage is 10 to 20 mg once daily, with adjustments made based on the patient's response and cholesterol levels [2].

It is important to note that Benadryl can cause drowsiness, and combining it with Lipitor or other medications may increase this effect [1]. Additionally, Lipitor may increase the risk of muscle damage when taken with certain medications, including some antihistamines [2].

In summary, while there is no specific recommended dosage for Benadryl use with Lipitor, it is crucial to consult a healthcare professional before combining the two medications. Patients should follow the recommended dosage for each medication individually and be aware of potential side effects and interactions [1][2].

Sources:
[1] "Benadryl" (diphenhydramine) drug label information. U.S. Food and Drug Administration. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/011528s047lbl.pdf>.
[2] "Lipitor" (atorvastatin) drug label information. Pfizer. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020272s045lbl.pdf>.
[3] "Drug Interactions: Atorvastatin and Diphenhydramine." DrugPatentWatch.com. <https://www.drugpatentwatch.com/interactions/atorvastatin-and-diphenhydramine>.