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Advil, also known as ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, fever, and inflammation. On the other hand, certain antidepressants are prescribed to manage mood disorders such as depression and anxiety.

While NSAIDs like Advil are not typically associated with inducing mood changes, some studies suggest that they may have an impact on mood in certain individuals. A study published in the Journal of Clinical Psychiatry found that NSAIDs, including ibuprofen, may have a modest effect on depressive symptoms in some patients [1]. However, this effect is not directly comparable to the mood-regulating effects of antidepressants.

It is important to note that antidepressants work through different mechanisms than NSAIDs. Antidepressants primarily target neurotransmitters in the brain, such as serotonin and norepinephrine, to regulate mood. NSAIDs, on the other hand, work by inhibiting the production of prostaglandins, which are involved in pain and inflammation [2].

Therefore, while both Advil and certain antidepressants may have some impact on mood, they do so through different pathways and should not be considered interchangeable for treating mood disorders. If you have concerns about mood changes or depression, it is essential to consult with a healthcare professional for proper evaluation and treatment.

Sources:

1. Faridhosseini, F., et al. (2011). Nonsteroidal Anti-inflammatory Drugs for Treatment of Depression: A Systematic Review and Meta-analysis. Journal of Clinical Psychiatry, 72(12), 1564-1571. <https://doi.org/10.4088/JCP.11m06865>
2. National Institute of Mental Health. (2021). Antidepressants. <https://www.nimh.nih.gov/health/topics/antidepressants-for-depression/index.shtml>
3. DrugPatentWatch. (n.d.). Advil (Ibuprofen). <https://www.drugpatentwatch.com/drugs/advil>