See the DrugPatentWatch profile for ibuprofen
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) used for treating pain, fever, and inflammation, does not directly affect Lipitor's cholesterol-lowering ability [1]. Lipitor, also known as atorvastatin, is a statin medication that helps lower cholesterol levels by reducing the production of cholesterol in the body [2].
Although ibuprofen does not interfere with Lipitor's primary function, it is essential to note that concurrent use of these two medications may increase the risk of certain side effects. For instance, both drugs are associated with an increased risk of developing muscle damage (rhabdomyolysis) when taken together, particularly at higher doses [3][4].
Additionally, NSAIDs like ibuprofen may affect the kidneys, and long-term use or high doses can increase the risk of kidney damage or kidney failure [5]. Since Lipitor and other statins are also processed by the kidneys, combining these medications may increase the risk of kidney-related side effects [6].
In summary, while ibuprofen does not directly affect Lipitor's cholesterol-lowering ability, concurrent use of these medications may increase the risk of certain side effects, such as muscle damage and kidney problems. Patients should consult their healthcare providers before using these medications together.
Sources:
1. "Ibuprofen." MedlinePlus, U.S. National Library of Medicine, 23 Feb. 2022, medlineplus.gov/druginfo/meds/a682035.html.
2. "Atorvastatin." MedlinePlus, U.S. National Library of Medicine, 11 Feb. 2022, medlineplus.gov/druginfo/meds/a603025.html.
3. "Atorvastatin and Ibuprofen." DrugPatentWatch, drugpatentwatch.com/drugs/atorvastatin-and-ibuprofen.
4. "Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)." Mayo Clinic, Mayo Foundation for Medical Education and Research, 16 Dec. 2020, mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/nonsteroidal-anti-inflammatory-drugs-nsaids/faq-20058034.
5. "Ibuprofen: MedlinePlus Drug Information." MedlinePlus, U.S. National Library of Medicine, medlineplus.gov/druginfo/meds/a682035.html.
6. "Statins." Mayo Clinic, Mayo Foundation for Medical Education and Research, 12 Jan. 2022, mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045781.