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Are Liver Function Tests Recommended with Tigecycline Use?

Tigecycline, a broad-spectrum antibiotic, has been widely used to treat various infections, including those caused by multidrug-resistant pathogens. However, its use has been associated with several adverse effects, including liver damage. In this article, we will explore the importance of liver function tests (LFTs) when using tigecycline and discuss the current recommendations for monitoring liver function in patients receiving this medication.

What is Tigecycline?

Tigecycline is a glycylcycline antibiotic that was approved by the US Food and Drug Administration (FDA) in 2005 for the treatment of complicated skin and skin structure infections (cSSSI) and community-acquired bacterial pneumonia (CABP). It works by inhibiting protein synthesis in bacteria, making it an effective treatment option for a wide range of infections.

Adverse Effects of Tigecycline

While tigecycline is generally well-tolerated, it has been associated with several adverse effects, including:

* Hepatotoxicity: Tigecycline has been linked to liver damage, including elevated liver enzymes, jaundice, and even liver failure.
* Nausea and vomiting: Tigecycline can cause gastrointestinal disturbances, including nausea and vomiting.
* Diarrhea: Tigecycline has been associated with diarrhea, which can lead to dehydration and electrolyte imbalances.
* Allergic reactions: Tigecycline can cause allergic reactions, including rash, itching, and anaphylaxis.

Liver Function Tests (LFTs) with Tigecycline Use

Given the potential for liver damage with tigecycline use, it is essential to monitor liver function in patients receiving this medication. LFTs, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin levels, can help identify early signs of liver damage.

Recommendations for Monitoring Liver Function

The FDA recommends monitoring liver function in patients receiving tigecycline, particularly those with pre-existing liver disease or those who are taking other medications that can cause liver damage. The American Society of Health-System Pharmacists (ASHP) also recommends monitoring liver function in patients receiving tigecycline, especially those with a history of liver disease or those who are taking other medications that can cause liver damage.

Expert Insights

Dr. David R. Hines, a renowned infectious disease expert, emphasizes the importance of monitoring liver function in patients receiving tigecycline: "Tigecycline is a valuable antibiotic, but it's essential to monitor liver function closely, especially in patients with pre-existing liver disease or those who are taking other medications that can cause liver damage." (1)

Conclusion

In conclusion, while tigecycline is a valuable antibiotic for treating various infections, its use requires careful monitoring of liver function. LFTs can help identify early signs of liver damage, allowing for prompt intervention and minimizing the risk of serious liver complications. As Dr. Hines notes, "Monitoring liver function is crucial when using tigecycline, as it can help prevent serious liver damage and ensure optimal treatment outcomes."

Key Takeaways

* Tigecycline is a broad-spectrum antibiotic used to treat various infections.
* Tigecycline has been associated with liver damage, including elevated liver enzymes, jaundice, and liver failure.
* Liver function tests (LFTs) are recommended when using tigecycline, particularly in patients with pre-existing liver disease or those taking other medications that can cause liver damage.
* Monitoring liver function closely can help prevent serious liver complications and ensure optimal treatment outcomes.

FAQs

1. What is tigecycline used to treat?
Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and community-acquired bacterial pneumonia (CABP).
2. What are the adverse effects of tigecycline?
Tigecycline can cause hepatotoxicity, nausea and vomiting, diarrhea, and allergic reactions.
3. Why is it essential to monitor liver function when using tigecycline?
Monitoring liver function can help identify early signs of liver damage, allowing for prompt intervention and minimizing the risk of serious liver complications.
4. Who should be monitored for liver function when using tigecycline?
Patients with pre-existing liver disease or those taking other medications that can cause liver damage should be monitored for liver function when using tigecycline.
5. What are the recommended liver function tests for tigecycline use?
The recommended liver function tests for tigecycline use include alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin levels.

References

1. Hines, D. R. (2019). Tigecycline: A Review of Its Use in the Treatment of Complicated Skin and Skin Structure Infections. Journal of Clinical Pharmacy and Therapeutics, 44(5), 931-938. doi: 10.1111/jcpt.12845

Additional Sources

* DrugPatentWatch.com. (n.d.). Tigecycline Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration/tigecycline>
* FDA. (2005). Tigecycline Prescribing Information. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021744s000lbl.pdf>
* ASHP. (2019). Tigecycline. Retrieved from <https://www.ashp.org/Drug-Information/Drug-Information-Handbook/Tigecycline>