See the DrugPatentWatch profile for tigecycline

Based on the information provided, I was unable to find specific data regarding comorbidities that worsen tigecycline's liver effects. However, I can provide some context about tigecycline and its potential liver toxicity.

Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections, including skin and soft tissue infections, intra-abdominal infections, and community-acquired pneumonia [1]. Like many other medications, tigecycline can have side effects, one of which is an increase in liver enzymes, which may indicate liver damage or inflammation [2].

Patients with preexisting liver conditions or those taking other medications that affect liver function may be at increased risk of liver toxicity when using tigecycline [3]. However, there is no specific information on which comorbidities, in particular, worsen tigecycline's liver effects. It is essential to monitor liver function closely in patients receiving tigecycline, especially those with preexisting liver disease or those taking concomitant medications that may affect liver function [3].

Sources:

1. FDA. (2010). Tigecycline (marketed as Tygacil) Information. <https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/tigecycline-marketed-tygacil-information>
2. UpToDate. (2022). Tigecycline: Drug Information. <https://www.uptodate.com/contents/tigecycline-drug-information>
3. DrugPatentWatch. (n.d.). Tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline/>