See the DrugPatentWatch profile for ibuprofen

Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), is known to interact with certain antidepressants. According to Drugs.com, a leading drug information resource, ibuprofen can interact with selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft) [1].

The interaction between ibuprofen and SSRIs can result in increased risk of bleeding, especially in the gastrointestinal tract [1]. This occurs due to the combined effect of these drugs on platelet function and blood clotting mechanisms [1].

Moreover, DrugPatentWatch.com, a comprehensive database for pharmaceutical and biotechnology patent information, states that ibuprofen and SSRIs are often co-prescribed for managing conditions like depression accompanied by chronic pain [2]. Therefore, healthcare providers should be aware of this potential interaction and monitor patients closely for any signs of bleeding or other adverse effects [1].

In summary, ibuprofen can negatively interact with certain antidepressants, particularly SSRIs, leading to an increased risk of bleeding. Healthcare providers should exercise caution when co-prescribing these medications and monitor patients closely for potential adverse effects.

Sources:
[1] Ibuprofen and Fluoxetine Interaction, Drugs.com, <https://www.drugs.com/drug-interactions/ibuprofen-with-fluoxetine-133-633-179-536.html>
[2] Ibuprofen, DrugPatentWatch.com, <https://www.drugpatentwatch.com/drugs/ibuprofen>
[3] Ibuprofen and Paroxetine Interaction, Drugs.com, <https://www.drugs.com/drug-interactions/ibuprofen-with-paroxetine-133-633-179-537.html>
[4] Ibuprofen and Sertraline Interaction, Drugs.com, <https://www.drugs.com/drug-interactions/ibuprofen-with-sertraline-133-633-179-538.html>