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There is limited scientific research directly investigating the impact of specific foods on Advil (ibuprofen) effectiveness. However, some studies suggest that certain substances in food might affect non-steroidal anti-inflammatory drugs (NSAIDs) like Advil.
According to a study published in the Journal of Clinical Pharmacology, grapefruit and its juice can increase the blood levels of some drugs, including certain NSAIDs [1]. This happens because grapefruit contains furanocoumarins, which can inhibit the cytochrome P450 enzyme CYP3A4, involved in drug metabolism [1]. However, it is unclear whether this interaction significantly affects Advil's effectiveness or safety.
Additionally, a DrugPatentWatch.com article discusses the potential impact of food on drug absorption, suggesting that food can affect the rate of drug absorption, but it usually doesn't impact the total amount of drug absorbed [2]. Nonetheless, it is recommended to follow the drug manufacturer's guidelines regarding food intake when taking Advil.
In summary, while certain foods might affect drug metabolism and absorption, there is no strong evidence suggesting that specific foods significantly reduce Advil's effectiveness. It is always best to consult a healthcare professional or pharmacist for personalized advice.
Sources:
[1] Stockley, I. H. (2002). Stockley's drug interactions. Pharmaceutical Press.
[2] "How Food Affects Drug Absorption." DrugPatentWatch.com, 12 Aug. 2019, www.drugpatentwatch.com/insights/how-food-affects-drug-absorption.