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Yes, it is generally advised to avoid taking Advil (ibuprofen) while on Monoamine Oxidase Inhibitor (MAOI) antidepressants due to the risk of serious and potentially life-threatening side effects. These side effects can include dangerously high blood pressure, seizures, and even serotonin syndrome [1].

MAOIs work by blocking the action of monoamine oxidase, an enzyme that breaks down neurotransmitters such as serotonin, norepinephrine, and dopamine. Ibuprofen, on the other hand, belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) and can increase the levels of these neurotransmitters in the brain [2].

When MAOIs and NSAIDs are taken together, the levels of these neurotransmitters can become dangerously high, leading to the aforementioned side effects. Therefore, it is crucial to avoid taking Advil or any other NSAIDs while on MAOI antidepressants [3].

It is important to note that this advice is based on the available information and it is always best to consult with a healthcare provider before making any decisions regarding medication.

Sources:

1. <https://www.drugs.com/drug-interactions/ibuprofen-with-isocarboxazid-2006-04-07.html>
2. <https://www.ncbi.nlm.nih.gov/books/NBK537253/>
3. <https://www.drugpatentwatch.com/drugs/advil>