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There is no definitive answer to whether it is best to take aspirin before or after bedtime for stroke prevention. According to the American Heart Association, aspirin therapy for stroke prevention is typically prescribed at a dose of 50-325 milligrams (mg) daily [1]. The time of day you take aspirin is generally not as important as consistently taking it at the same time each day [2].

It is important to consult with your healthcare provider before starting or changing any medication regimen. They can provide personalized advice based on your specific medical history and current health status.

In summary, while there is no clear evidence that taking aspirin before or after bedtime has a significant impact on stroke prevention, it is crucial to take it consistently and as directed by your healthcare provider.

Sources:
[1] American Heart Association. (2021). Aspirin and Heart Disease. <https://www.heart.org/en/health-topics/heart-attack/treatment-of-a-heart-attack/aspirin-and-heart-disease>
[2] Mayo Clinic. (2020). Aspirin: Does the time of day matter? <https://www.mayoclinic.org/diseases-conditions/heart-disease/expert-answers/aspirin/faq-20057806>
[3] DrugPatentWatch.com. (2022). Aspirin. <https://www.drugpatentwatch.com/drugs/aspirin>