See the DrugPatentWatch profile for stiripentol

Stiripentol and fenfluramine are both drugs used for the treatment of certain medical conditions, but they reduce excitability in the body through different mechanisms.
Stiripetol is an anticonvulsant medication primarily used as an add-on treatment for refractory generalized epilepsy in children and adolesc1234567890. It is a positive allosteric modulator of the GABA-A receptor, which increases the frequency of chloride ion (Cl-) influx upon binding of GABA, resulting in hyperpolarization of the neuronal membrane and decreased neuronal excitability1234567890.
Fenfluramine, on the other hand, is a serotonin agonist that has been used for the treatment of obesity and, more recently, for the treatment of Dravet syndrome, a severe form of epilepsy234567890. Fenfluramine works by increasing the release of serotonin from presynaptic neurons and inhibiting its reuptake, leading to an increase in serotonin levels in the synaptic cleft234567890.
In summary, stiripent Sources:
1. <https://www.ncbi.roles and fenfluramine reduce excitability differently. Stiripentol increases the frequency of chloride ion influx through the GABA-A receptor, leading to hyperpolarization of the neuronal membrane and decreased neuronal excitability. Fenfluramine, on the other hand, increases serotonin levels in the synaptic cleg-medication-drug-disease-condition-77739-98.html>
2. <https://www.ncbi.g/2306665>
3. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654422/>
4. <https://www.ncbi.98/2654422/>
5. <https://www.ncbi.nlm.nih.g/2306665>
6. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898456/>
7. <https://www.ncbi.nlm.nih.ime-disorder-associated-with-fenfluramine-use-in-dravet-syndrome-a-case-report/>
8. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085143/>
9. <https://www.ncbi.nlm.nih.g/2306665>
0. <https://www.drugpatentwatch.com/Drug%20Pipeline/Drugs%2+20by%20Mechanism%20of%20Action/Anticonvulsants%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2rine increases serotonin levels in the synaptic cleft, leading to a decrease in neuronal excitability.

*Note: The above information is based on the available sources and is not intended as medical advice. Always consult with a healthcare provider for medical advice.*