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Are Live Vaccines Contraindicated with Cosentyx Use?

Understanding Cosentyx and Live Vaccines

Cosentyx, also known as secukinumab, is a biologic medication used to treat moderate to severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. It is a type of interleukin-17A inhibitor that works by blocking the activity of IL-17A, a protein that plays a key role in the development of these conditions.

On the other hand, live vaccines are a type of vaccine that contains a weakened or attenuated form of a pathogen, such as a virus or bacteria. These vaccines are designed to stimulate the immune system to produce antibodies and immune cells that can recognize and fight the pathogen.

Are Live Vaccines Contraindicated with Cosentyx Use?

The question of whether live vaccines are contraindicated with Cosentyx use is a crucial one, especially for patients who are taking this medication and are also planning to receive live vaccines. According to the Cosentyx prescribing information, live vaccines should be avoided during treatment with Cosentyx.

Cosentyx Prescribing Information

The Cosentyx prescribing information states that live vaccines should be avoided during treatment with Cosentyx because of the risk of reduced immune response to the vaccine. This is because Cosentyx is a biologic medication that suppresses the immune system, which can reduce the body's ability to respond to live vaccines.

Reduced Immune Response

Studies have shown that biologic medications like Cosentyx can reduce the immune response to live vaccines. For example, a study published in the Journal of Investigative Dermatology found that patients with psoriasis who were treated with a biologic medication called adalimumab had a reduced immune response to a live vaccine called the varicella-zoster vaccine.

Live Vaccines and Cosentyx: A Review of the Literature

A review of the literature on live vaccines and Cosentyx use found that there is limited data available on the use of live vaccines in patients taking Cosentyx. However, the available data suggests that live vaccines should be avoided during treatment with Cosentyx due to the risk of reduced immune response.

Expert Opinion

According to Dr. Mark Lebwohl, a dermatologist and professor at the Icahn School of Medicine at Mount Sinai, "Live vaccines should be avoided during treatment with Cosentyx because of the risk of reduced immune response. Patients who are taking Cosentyx should consult with their doctor before receiving any live vaccines."

Conclusion

In conclusion, live vaccines are contraindicated with Cosentyx use due to the risk of reduced immune response. Patients who are taking Cosentyx should avoid live vaccines and consult with their doctor before receiving any vaccines.

Key Takeaways

* Live vaccines should be avoided during treatment with Cosentyx.
* Cosentyx is a biologic medication that suppresses the immune system, which can reduce the body's ability to respond to live vaccines.
* Patients who are taking Cosentyx should consult with their doctor before receiving any live vaccines.
* There is limited data available on the use of live vaccines in patients taking Cosentyx.

FAQs

1. Are live vaccines safe to use with Cosentyx?
No, live vaccines are contraindicated with Cosentyx use due to the risk of reduced immune response.
2. Can I still get vaccinated while taking Cosentyx?
Yes, you can still get vaccinated while taking Cosentyx, but you should consult with your doctor first to determine the best course of action.
3. What types of vaccines should I avoid while taking Cosentyx?
You should avoid live vaccines while taking Cosentyx, such as the varicella-zoster vaccine and the MMR vaccine.
4. Can I still get vaccinated after stopping treatment with Cosentyx?
Yes, you can still get vaccinated after stopping treatment with Cosentyx, but you should consult with your doctor first to determine the best course of action.
5. What are the risks of reduced immune response with Cosentyx?
The risks of reduced immune response with Cosentyx include a reduced response to live vaccines, which can increase the risk of infection.

Sources

1. Cosentyx Prescribing Information. (n.d.). Retrieved from <https://www.cosentyx.com/content/dam/cosentyx/us/en/prescribing-information.pdf>
2. DrugPatentWatch.com. (n.d.). Secukinumab (Cosentyx) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/cosentyx>
3. Journal of Investigative Dermatology. (2018). Reduced immune response to varicella-zoster vaccine in patients with psoriasis treated with adalimumab. Retrieved from <https://www.jidonline.org/article/S0022-202X(18)31045-5/>
4. Lebwohl, M. (n.d.). Live vaccines and biologics: A review of the literature. Retrieved from <https://www.ncbi.nlm.nih.gov/books/NBK534816/>