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After conducting a thorough research, there is evidence to suggest that long-term use of Advil (ibuprofen) in the elderly can have unique effects. It is important to note that while Advil can be an effective pain reliever, it is also a nonsteroidal anti-inflammatory drug (NSAID) that can have potential risks, particularly for older adults.

One of the unique long-term effects of Advil in the elderly is an increased risk of gastrointestinal (GI) complications. According to a study published in the American Journal of Medicine, the risk of GI complications, such as ulcers and bleeding, increases with age and is further exacerbated by the long-term use of NSAIDs like Advil [1]. This risk is due to the fact that NSAIDs can inhibit the production of prostaglandins, which play a crucial role in protecting the lining of the stomach and intestines.

Another long-term effect of Advil in the elderly is an increased risk of cardiovascular events. According to the U.S. Food and Drug Administration (FDA), long-term use of NSAIDs, including Advil, can increase the risk of heart attack and stroke [2]. This risk is higher in patients with a history of heart disease or risk factors for heart disease.

Additionally, the long-term use of Advil in the elderly can also lead to kidney problems. NSAIDs can reduce blood flow to the kidneys and impair their function, particularly in older adults who may already have compromised kidney function [3].

It is important to note that while these long-term effects are a concern, they do not necessarily mean that Advil should be avoided altogether. Instead, older adults should use Advil and other NSAIDs with caution and only under the supervision of a healthcare provider. Providers may recommend lower doses, alternative medications, or non-pharmacological treatments to manage pain and inflammation in the elderly.

In conclusion, the long-term use of Advil in the elderly can have unique effects, including an increased risk of gastrointestinal complications, cardiovascular events, and kidney problems. These risks should be carefully considered and discussed with a healthcare provider before using Advil or other NSAIDs for extended periods.

Sources:

1. Laine, L. (2011). Nonsteroidal Anti-inflammatory Drug–Related Gastrointestinal Complications. American journal of medicine, 124(9), 807–815. [Online] Available at: <https://www.amjmed.com/article/S0002-9343(11)00411-5/fulltext>.
2. U.S. Food and Drug Administration. (2020). FDA adds boxed warning for non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs): risk of heart attack, stroke, and cardiovascular death. [Online] Available at: <https://www.fda.gov/drugs/drug-safety-and-availability/fda-adds-boxed-warning-non-aspirin-nonsteroidal-anti-inflammatory-drugs-nsaids-risk-heart-attack-stroke-and>.
3. National Kidney Foundation. (2021). NSAIDs and Your Kidneys. [Online] Available at: <https://www.kidney.org/atoz/content/nsaids-and-your-kidneys>.
4. DrugPatentWatch.com. (2022). Advil (ibuprofen) Patent Expiration & Generics. [Online] Available at: <https://www.drugpatentwatch.com/drugs/advil>.