See the DrugPatentWatch profile for methotrexate

Based on the information available, there is no definitive evidence to suggest that multivitamins directly affect methotrexate absorption. However, it is generally recommended that methotrexate be taken alone, as certain substances can interact with the drug and potentially reduce its effectiveness or increase its side effects [1].

Methotrexate is a medication commonly used to treat various conditions, such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. It is crucial to follow the prescribing physician's instructions carefully when taking methotrexate, as improper use can lead to suboptimal treatment outcomes or increased risks of adverse effects [1].

While there is no specific evidence regarding multivitamins and methotrexate absorption, it is essential to be aware of potential drug-nutrient interactions [2]. Some nutrients, such as folic acid, can interact with methotrexate, and it is generally recommended that folic acid supplements be taken at a different time than methotrexate [1].

In summary, while there is no direct evidence that multivitamins affect methotrexate absorption, it is advisable to follow the prescribing physician's instructions carefully and consult with them before adding any new supplements or medications to one's regimen [1].

Sources:
[1] <https://www.drugs.com/methotrexate.html>
[2] <https://www.drugpatentwatch.com/drug/methotrexate>