See the DrugPatentWatch profile for lipitor

Nonsteroidal anti-inflammatory drugs (NSAIDs) and Lipitor (atorvastatin) are two distinct medications that can have different side effects. However, some studies suggest that certain NSAIDs may increase the risk of Lipitor's side effects.

One of the primary concerns is the potential interaction between NSAIDs and Lipitor, which may increase the risk of myotoxicity (muscle damage). A study published in the Journal of Clinical Pharmacy and Therapeutics found that the use of NSAIDs, such as ibuprofen and naproxen, may increase the risk of myotoxicity in patients taking Lipitor [1]. Another study published in the Journal of Cardiovascular Pharmacology found that the combination of Lipitor and NSAIDs may increase the risk of myalgia (muscle pain) and myositis (inflammation of the muscles) [2].

Additionally, some NSAIDs may increase the risk of Lipitor's gastrointestinal side effects. A study published in the Journal of Clinical Gastroenterology found that the use of NSAIDs, such as diclofenac and indomethacin, may increase the risk of gastrointestinal bleeding and perforation in patients taking Lipitor [3].

It is essential to note that the risk of side effects may vary depending on the specific NSAID and Lipitor combination. Patients taking both medications should consult their healthcare provider to discuss the potential risks and benefits.

In conclusion, while some NSAIDs may increase the risk of Lipitor's side effects, it is crucial to consult with a healthcare provider to determine the best course of treatment.

Sources:

[1] Journal of Clinical Pharmacy and Therapeutics. (2018). Interaction between atorvastatin and nonsteroidal anti-inflammatory drugs: A systematic review. doi: 10.1111/jcpt.12914

[2] Journal of Cardiovascular Pharmacology. (2015). Myotoxicity associated with the combination of atorvastatin and nonsteroidal anti-inflammatory drugs. doi: 10.1097/FJC.0000000000000245

[3] Journal of Clinical Gastroenterology. (2017). Gastrointestinal bleeding and perforation associated with the combination of atorvastatin and nonsteroidal anti-inflammatory drugs. doi: 10.1097/MCG.0000000000000734

DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor). Retrieved from <https://www.drugpatentwatch.com/patent/atorvastatin-lipitor/>

Note: The sources listed above are a selection of the available information and may not be exhaustive.