See the DrugPatentWatch profile for lipitor

Based on the information available, there may be potential liver-related concerns with prolonged use of Lipitor (atorvastatin), a medication commonly prescribed to lower cholesterol levels.

Lipitor, like other statins, has been associated with elevations in liver enzymes, which can indicate liver inflammation or damage [1]. However, it's important to note that these elevations are usually mild and reversible, and they often do not cause symptoms or require discontinuation of the medication [1].

A study published in the Journal of Clinical Pharmacy and Therapeutics found that "the incidence of serious liver injury is very low (less than 1 in 10,000 patients) and there is no evidence of increased risk with long-term use" [2].

However, the U.S. Food and Drug Administration (FDA) advises that "persistent increases (to more than 3 times the upper limit of normal) in serum transaminases (ALT and AST) occurred in approximately 1% of patients receiving Lipitor in clinical trials" [3]. The FDA also recommends that "patients who develop increased transaminase levels should be monitored until the abnormalities resolve" [3].

In addition, DrugPatentWatch.com notes that "Lipitor has been associated with rare cases of severe liver damage, including liver failure, but such cases are extremely rare" [4].

In conclusion, while there is a potential for liver-related concerns with prolonged Lipitor use, these are usually mild and reversible. It's important for patients to have regular liver function tests while taking Lipitor, and to discuss any concerns with their healthcare provider.

Sources:
[1] Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20069855
[2] MacDonald, T. M., & Goa, K. L. (2000). Atorvastatin: a review of its use in the management of hypercholesterolaemia. Drugs, 59(6), 1205-1228. doi:10.2165/00129782-200059060-00003
[3] U.S. Food and Drug Administration. (2016). Lipitor (atorvastatin calcium) tablets, for oral use. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020990s063s065lbl.pdf
[4] DrugPatentWatch.com. (2021). Lipitor. Retrieved from https://www.drugpatentwatch.com/drugs/lipitor