See the DrugPatentWatch profile for lipitor

The dosage of Lipitor, a medication used to treat high cholesterol, may be affected by kidney function. This is because the kidneys play a crucial role in eliminating Lipitor from the body [1].

Lipitor, also known as atorvastatin, is primarily metabolized by the liver and excreted by the kidneys. Approximately 7% of Lipitor is excreted unchanged in the urine [2]. Therefore, impaired kidney function may lead to an accumulation of Lipitor in the body, increasing the risk of side effects.

The prescribing information for Lipitor recommends a starting dose of 10-20mg once daily for patients with mild to moderate kidney impairment [3]. For patients with severe kidney impairment, including those on dialysis, the starting dose should be 10mg once daily, and the dose should not exceed 20mg once daily [3].

It is important to note that healthcare providers may adjust Lipitor dosages based on individual patient circumstances, including kidney function [1]. Therefore, it is essential to inform healthcare providers of any changes in kidney function or other health status [1].

In summary, kidney function can impact Lipitor dosage due to the kidneys' role in eliminating the medication from the body. Healthcare providers may adjust Lipitor dosages based on kidney function and individual patient circumstances.

Sources:
[1] Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20069051?p=1>
[2] DrugPatentWatch. (2021). Lipitor (Atorvastatin Calcium). Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>
[3] Pfizer Labs. (2016). Lipitor (Atorvastatin Calcium) Tablets, for Oral Use. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/20267s118,20267s120,20267s122lbl.pdf>