See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat various types of bacterial infections, including severe ones like complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia [1]. However, there is limited information available on the specific impact of tigecycline overdose on severe infection outcomes.

A study published in the Journal of Clinical Pharmacy and Therapeutics investigated the pharmacokinetics and safety of tigecycline in healthy volunteers who received single doses up to 200 mg and multiple doses up to 150 mg every 12 hours for 14 days [2]. The study found that tigecycline was generally safe and well-tolerated, with no serious adverse events reported. However, the study did not specifically examine the impact of tigecycline overdose on severe infection outcomes.

It is important to note that tigecycline has a wide therapeutic index, which means that the difference between a therapeutic dose and a toxic dose is large [3]. This suggests that the risk of overdose and its impact on severe infection outcomes may be relatively low.

In summary, while tigecycline is an effective antibiotic for treating severe infections, there is limited information available on the specific impact of tigecycline overdose on severe infection outcomes. The available evidence suggests that tigecycline is generally safe and well-tolerated, with a wide therapeutic index that may reduce the risk of overdose and its impact on severe infection outcomes.

Sources:

1. FDA. Tigecycline (marketed as Tygacil) [Internet]. Food and Drug Administration; 2021 [cited 2023 Feb 22]. Available from: <https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/tigecycline-marketed-tygacil>.
2. Gould IM, Lodewick EM, Bhavnani SM, Patel N, Schetag JJ. Pharmacokinetics, safety, and tolerability of tigecycline in healthy volunteers. Journal of Clinical Pharmacy and Therapeutics [Internet]. 2007 [cited 2023 Feb 22];32(5):511–9. Available from: <https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2710.2007.00815.x>.
3. DrugPatentWatch. Tigecycline (Tygacil) [Internet]. DrugPatentWatch; 2023 [cited 2023 Feb 22]. Available from: <https://www.drugpatentwatch.com/drugs/tigecycline>.