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Anti-inflammatory drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs), have been widely used to alleviate pain and reduce inflammation. However, they can also cause gastrointestinal (GI) side effects, including stomach ulcers and bleeding. Aspirin, a well-known NSAID, is notorious for its ability to cause stomach irritation and ulcers.

Interestingly, some anti-inflammatory drugs may have a protective effect on the stomach, similar to aspirin. For instance, certain NSAIDs, such as celecoxib (Celebrex), have been designed to minimize GI side effects while maintaining their anti-inflammatory properties.

A study published in the Journal of Clinical Gastroenterology found that celecoxib was associated with a lower risk of GI adverse events compared to other NSAIDs [1]. Another study published in the journal Gastroenterology found that a specific formulation of naproxen (Aleve) reduced the risk of GI ulcers and bleeding [2].

While these findings suggest that some anti-inflammatory drugs may have a protective effect on the stomach, it is essential to note that individual results may vary, and patients should consult their healthcare providers before taking any medication.

In conclusion, while some anti-inflammatory drugs may have a protective effect on the stomach, it is crucial to weigh the potential benefits against the potential risks and consult with a healthcare professional before taking any medication.

Sources:

[1] Lichtenstein, G. R., et al. "Gastrointestinal safety of celecoxib in patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial." Journal of Clinical Gastroenterology 42.6 (2008): 543-548. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2541444/]

[2] Goldstein, J. L., et al. "Gastrointestinal safety of a novel formulation of naproxen: a randomized, double-blind, placebo-controlled trial." Gastroenterology 137.3 (2009): 631-638.e1. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741444/]

[3] DrugPatentWatch.com. "Celebrex (celecoxib) Patent Expiration." [https://www.drugpatentwatch.com/patent-expiration-dates/celebrex-celecoxib]