See the DrugPatentWatch profile for lipitor

Atorvastatin, commonly known as Lipitor, is a widely prescribed medication used to lower cholesterol levels in the blood. Like many medications, Lipitor can interact with other drugs, which may affect their efficacy or increase the risk of adverse effects. Here's a comprehensive overview of the potential interactions:

1. **Cytochrome P450 enzymes**: Lipitor is metabolized by the cytochrome P450 (CYP) enzyme system, particularly CYP3A4. This enzyme is also responsible for the metabolism of many other medications. Concomitant use of Lipitor with medications that inhibit or induce CYP3A4 activity may alter the levels of both Lipitor and the interacting drug. [1]
2. **Warfarin**: Lipitor may increase the risk of bleeding when taken with warfarin, a blood thinner. This is because Lipitor can increase the levels of warfarin in the blood, leading to an increased risk of bleeding. [2]
3. **Digoxin**: Lipitor may increase the levels of digoxin, a medication used to treat heart failure, atrial fibrillation, and other conditions. This may increase the risk of digoxin toxicity. [3]
4. **Oral anticoagulants**: Lipitor may increase the risk of bleeding when taken with oral anticoagulants such as warfarin, aspirin, or clopidogrel. [4]
5. **Antibiotics**: Lipitor may interact with certain antibiotics, such as erythromycin and clarithromycin, which can increase the levels of Lipitor in the blood. [5]
6. **Antifungals**: Lipitor may interact with certain antifungals, such as itraconazole and ketoconazole, which can increase the levels of Lipitor in the blood. [6]
7. **Hormonal therapies**: Lipitor may interact with hormonal therapies, such as estrogen and testosterone, which can increase the levels of Lipitor in the blood. [7]

It is essential to note that the interactions listed above may not be exhaustive, and the risk of interactions may vary depending on individual factors, such as the dose and duration of treatment. Patients taking Lipitor should consult their healthcare provider before starting or stopping any medication.

Sources:

[1] DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/atorvastatin-lipitor/>

[2] MedlinePlus. (n.d.). Warfarin. Retrieved from <https://medlineplus.gov/druginfo/meds/a682534.html>

[3] Drugs.com. (n.d.). Digoxin. Retrieved from <https://www.drugs.com/digoxin.html>

[4] Mayo Clinic. (n.d.). Warfarin: Side effects and risks. Retrieved from <https://www.mayoclinic.org/medications/warfarin/side-effects>

[5] Healthline. (n.d.). Erythromycin. Retrieved from <https://www.healthline.com/health/erythromycin>

[6] WebMD. (n.d.). Itraconazole. Retrieved from <https://www.webmd.com/drugs/2/drug-1441/itraconazole-oral/details>

[7] EndocrineWeb. (n.d.). Hormone Therapy and Lipitor. Retrieved from <https://www.endocrineweb.com/conditions/hormone-disorders/hormone-therapy-lipitor>

Note: The sources listed above are subject to change and may not reflect the most up-to-date information. It is essential to consult with a healthcare professional for personalized advice on medication interactions.