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According to the information provided, you are inquiring about the safe frequency of taking 325mg of aspirin per day. After conducting research using the available information, I found that the standard recommended dose of aspirin for adults is up to 325mg every 4-6 hours, not to exceed 3,900mg in 24 hours [1]. However, it is crucial to consult a healthcare professional before starting or changing any medication regimen, as individual needs and health conditions may impact the safety and efficacy of aspirin use [2].

Additionally, it is important to note that long-term use of aspirin, particularly at high doses, can have adverse effects, such as gastrointestinal bleeding and ulcers [3]. Therefore, it is essential to weigh the potential risks and benefits of aspirin use with a healthcare provider.

In summary, while the standard recommended dose of aspirin for adults is up to 325mg every 4-6 hours, it is crucial to consult a healthcare professional for personalized advice regarding the safe frequency of aspirin use.

Sources:
[1] Drugs.com. (2022). Aspirin. Retrieved from <https://www.drugs.com/aspirin.html>
[2] Mayo Clinic. (2021). Aspirin (Acetylsalicylic Acid). Retrieved from <https://www.mayoclinic.org/drugs-supplements/aspirin/description/drg-20068891>
[3] DrugPatentWatch.com. (2022). Aspirin. Retrieved from <https://www.drugpatentwatch.com/drugs/aspirin>