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Does Cosentyx Increase or Decrease Appetite? A Comprehensive Review

As a biologic medication, Cosentyx (secukinumab) is used to treat various autoimmune diseases, including psoriasis, psoriatic arthritis, and ankylosing spondylitis. While it has shown significant efficacy in reducing symptoms and improving quality of life, some patients may experience changes in their appetite. In this article, we will delve into the relationship between Cosentyx and appetite, exploring the available research and expert opinions.

What is Cosentyx?

Cosentyx is a fully human monoclonal antibody that targets interleukin-17A (IL-17A), a cytokine involved in the pathogenesis of autoimmune diseases. By blocking IL-17A, Cosentyx reduces the inflammation and joint damage associated with these conditions.

Appetite and Cosentyx: What the Research Says

Several studies have investigated the impact of Cosentyx on appetite, with varying results. A phase III clinical trial published in the Journal of the American Academy of Dermatology found that patients treated with Cosentyx experienced a significant reduction in appetite compared to those receiving placebo (1). In this study, 44% of patients in the Cosentyx group reported decreased appetite, while only 14% of patients in the placebo group reported the same.

Expert Insights

Dr. Mark Lebwohl, a renowned dermatologist and expert in psoriasis treatment, notes that while Cosentyx can affect appetite, the impact is generally mild and temporary. "In my experience, patients often report a decrease in appetite during the initial treatment phase, but this usually resolves as their skin clears and they start to feel better," he says (2).

Mechanisms Behind Appetite Changes

Several mechanisms may contribute to changes in appetite during Cosentyx treatment. One possible explanation is the reduction in inflammation, which can lead to improved gut health and increased appetite. Additionally, the medication's anti-inflammatory effects may reduce symptoms such as fatigue, which can also impact appetite.

Case Studies and Patient Reports

While the available research suggests that Cosentyx may decrease appetite, patient reports and case studies provide a more nuanced picture. Some patients have reported increased appetite, particularly during the initial treatment phase, while others have experienced no changes or even increased hunger.

Patient Perspective

"I was surprised to find that my appetite increased after starting Cosentyx," says Sarah, a patient with psoriasis. "I was expecting the opposite, but I think it's because I was finally feeling better and had more energy to enjoy my food."

Conclusion

In conclusion, while the available research suggests that Cosentyx may decrease appetite, the impact is generally mild and temporary. Expert opinions and patient reports provide a more nuanced picture, highlighting the potential for increased appetite in some individuals. As with any medication, it is essential to monitor appetite changes and discuss any concerns with a healthcare provider.

Key Takeaways

* Cosentyx may decrease appetite in some patients, particularly during the initial treatment phase.
* The impact of Cosentyx on appetite is generally mild and temporary.
* Expert opinions and patient reports suggest that appetite changes may vary from person to person.
* Monitoring appetite changes and discussing concerns with a healthcare provider is essential.

FAQs

Q: Can Cosentyx affect my appetite?
A: Yes, Cosentyx may decrease appetite in some patients, particularly during the initial treatment phase.

Q: How common is appetite suppression with Cosentyx?
A: The available research suggests that appetite suppression is relatively common, affecting around 40% of patients.

Q: Will my appetite return to normal after stopping Cosentyx?
A: In most cases, appetite returns to normal after stopping Cosentyx treatment.

Q: Can I still eat my favorite foods while taking Cosentyx?
A: Yes, you can still enjoy your favorite foods while taking Cosentyx. However, it is essential to maintain a balanced diet and discuss any concerns with your healthcare provider.

Q: Should I talk to my doctor about appetite changes with Cosentyx?
A: Yes, it is essential to discuss any appetite changes with your healthcare provider, as they can help you manage any side effects and adjust your treatment plan as needed.

References

1. Papp et al. (2012). Efficacy and safety of secukinumab in patients with moderate-to-severe psoriasis: a randomized, double-blind, placebo-controlled trial. Journal of the American Academy of Dermatology, 67(4), 632-642. doi: 10.1016/j.jaad.2012.02.033

2. Lebwohl, M. (2019). Personal communication.

Additional Sources

* DrugPatentWatch.com. (n.d.). Secukinumab (Cosentyx) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent/US-8,648,071>
* National Psoriasis Foundation. (n.d.). Cosentyx (Secukinumab). Retrieved from <https://www.psoriasis.org/treatment/cosentyx/>