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Taking Advil, a brand name for the drug ibuprofen, without water is not ideal and can potentially lead to negative side effects. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain, reduce inflammation, and lower fever [1].

When taking medication, it is crucial to follow the instructions provided by the manufacturer or a healthcare professional to ensure the drug's optimal effectiveness and to reduce the risk of adverse effects. According to Drugs.com, ibuprofen can be taken with or without food, but it is recommended to take it with a full glass of water to facilitate proper absorption and reduce the risk of stomach irritation [2].

Taking Advil without water might not be as effective because it could lead to incomplete dissolution and absorption of the drug, which can affect its potency and onset of action. Moreover, not drinking enough water while taking ibuprofen can increase the risk of stomach ulcers and other gastrointestinal side effects [3].

In summary, it is less effective and potentially harmful to take Advil without water. It is recommended to follow the instructions provided by the manufacturer or a healthcare professional and take the medication with a full glass of water to ensure its optimal effectiveness and minimize the risk of adverse effects.

Sources:

1. Ibuprofen. (2021, March 12). In Mayo Clinic. Retrieved March 15, 2023, from https://www.mayoclinic.org/drugs-supplements/ibuprofen/description/drg-20063430
2. Ibuprofen: Drug information. (n.d.). In Drugs.com. Retrieved March 15, 2023, from https://www.drugs.com/ibuprofen.html
3. Ibuprofen. (2021, November 1). In DrugPatentWatch. Retrieved March 15, 2023, from https://www.drugpatentwatch.com/drugs/ibuprofen