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Yes, NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) like ibuprofen can affect methotrexate's efficacy. Concurrent use of NSAIDs and methotrexate can lead to reduced methotrexate effectiveness [1]. This is because NSAIDs can displace methotrexate from its protein-binding sites, increasing methotrexate clearance and reducing its concentration in the body [1][2].

Moreover, NSAIDs can exacerbate methotrexate-induced gastrointestinal toxicity, leading to decreased methotrexate absorption and further reducing its efficacy [1]. Therefore, it is recommended to use NSAIDs with caution in individuals taking methotrexate and to closely monitor their response to methotrexate therapy [1].

Sources:
[1] <https://www.ncbi.nlm.nih.gov/books/NBK551668/>
[2] <https://drugpatentwatch.com/methotrexate-ibuprofen-interaction/>