See the DrugPatentWatch profile for lipitor

Based on the information provided, I will assume you are inquiring about potential liver problems associated with the usage of Lipitor, a medication commonly prescribed to lower cholesterol levels.

Lipitor, also known as atorvastatin, has been linked to rare cases of liver problems [1]. However, it is essential to note that these instances are infrequent, and the benefits of Lipitor typically outweigh the potential risks.

During Lipitor's clinical trials, a small percentage of patients (0.5-0.6%) experienced elevated liver enzymes, which could indicate liver issues [1]. Nonetheless, these elevations were typically mild and transient, returning to normal levels without any specific treatment.

The U.S. Food and Drug Administration (FDA) mandates that Lipitor's label includes a warning about the potential for liver problems [2]. Healthcare professionals are advised to monitor liver function tests before initiating Lipitor therapy and periodically thereafter [2].

Patients should consult their healthcare provider if they experience any symptoms of liver issues, such as:

1. Loss of appetite
2. Nausea
3. Upper abdominal pain
4. Dark urine
5. Yellowing of the skin or eyes (jaundice)

In conclusion, while Lipitor has been associated with rare cases of liver problems, the occurrence is generally low. Patients should remain vigilant for potential symptoms and consult their healthcare provider if they have any concerns.

Sources:
[1] DrugPatentWatch.com. (n.d.). Lipitor (Atorvastatin) - DrugPatentWatch. Retrieved from https://www.drugpatentwatch.com/drugs/lipitor
[2] U.S. Food and Drug Administration. (2016, December). Lipitor (Atorvastatin Calcium) Tablets, for Oral Use [Label]. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/20267s125,20268s118,20269s109lbl.pdf