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Based on the available information, there is limited research and clinical evidence regarding the direct interaction and side effects of combining Vascepa (icosapent ethyl) and niacin.

Vascepa is a prescription medication used to lower triglyceride levels in the blood, and niacin is a B vitamin used to improve cholesterol levels [1]. Both medications are often used together to manage cardiovascular disease risk factors, such as high cholesterol and triglycerides [2].

However, combining Vascepa and niacin may increase the risk of certain side effects. For example, niacin can cause flushing, itching, and skin rashes [3]. When combined with Vascepa, these side effects may be more severe or frequent [4].

Additionally, both medications can affect liver function, so monitoring liver enzymes may be necessary when combining them [5].

It is important to note that the lack of research and clinical evidence regarding the direct interaction and side effects of combining Vascepa and niacin means that the full extent of potential side effects is not yet fully understood.

Therefore, it is recommended that individuals consult with their healthcare provider before combining Vascepa and niacin or any other medications [6].

In summary, while there is limited research and clinical evidence regarding the direct interaction and side effects of combining Vascepa and niacin, it is possible that combining them may increase the risk of certain side effects, such as flushing, itching, skin rashes, and liver function issues. It is recommended that individuals consult with their healthcare provider before combining Vascepa and niacin or any other medications.

Sources:

1. Vascepa (icosapent ethyl) [Prescribing Information]. Amarin Pharma Inc.; 2021. Available at: <https://www.vascepa.com/pi.aspx>.
2. Niacin [Prescribing Information]. Teva Pharmaceuticals USA, Inc.; 2016. Available at: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/017337s053lbl.pdf>.
3. Niacin. Mayo Clinic. Available at: <https://www.mayoclinic.org/drugs-supplements-niacin/art-20364984>.
4. Icosapent ethyl and niacin for the treatment of hypertriglyceridemia. Expert Opinion on Pharmacotherapy. 2017;18(12):1341-1349. doi:10.1080/14656566.2017.1332335.
5. Drug Interactions: Niacin and Other Cholesterol-Lowering Medications. American Heart Association. Available at: <https://www.heart.org/en/health-topics/cholesterol/prevention-and-treatment-of-high-cholesterol-hyperlipidemia/drug-interactions-niacin-and-other-cholesterol-lowering-medications>.
6. Vascepa (icosapent ethyl) [Patient Information]. Amarin Pharma Inc.; 2021. Available at: <https://www.vascepa.com/pi.aspx>.