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Long-Term Side Effects of Keytruda: What You Need to Know

What is Keytruda?

Keytruda, also known as pembrolizumab, is a medication used to treat various types of cancer, including melanoma, lung cancer, and classical Hodgkin lymphoma. It is a type of immunotherapy that works by boosting the body's natural defenses to fight cancer cells.

What are the Common Side Effects of Keytruda?

Like any medication, Keytruda can cause side effects. The most common side effects of Keytruda include:

* Fatigue
* Musculoskeletal pain
* Nausea
* Diarrhea
* Rash
* Itching
* Hives
* Fever
* Chills

What are the Long-Term Side Effects of Keytruda?

While the common side effects of Keytruda are often manageable and temporary, some patients may experience long-term side effects. According to the FDA, the long-term side effects of Keytruda can include:

Immune-Related Adverse Reactions

* Hypophysitis: Inflammation of the pituitary gland, which can lead to hormonal imbalances.
* Thyroiditis: Inflammation of the thyroid gland, which can lead to hypothyroidism or hyperthyroidism.
* Adrenal Insufficiency: Inflammation of the adrenal glands, which can lead to fatigue, weakness, and low blood pressure.
* Type 1 Diabetes Mellitus: A condition characterized by high blood sugar levels and a need for insulin therapy.

Other Long-Term Side Effects

* Pneumonitis: Inflammation of the lungs, which can lead to coughing, shortness of breath, and chest pain.
* Colitis: Inflammation of the colon, which can lead to diarrhea, abdominal pain, and weight loss.
* Hepatitis: Inflammation of the liver, which can lead to fatigue, nausea, and yellowing of the skin and eyes.
* Neurological Toxicities: Conditions such as Guillain-Barré syndrome, myasthenia gravis, and peripheral neuropathy.

Managing Long-Term Side Effects

While long-term side effects of Keytruda can be serious, they can often be managed with medication and lifestyle changes. Patients should work closely with their healthcare provider to monitor their condition and adjust their treatment plan as needed.

Conclusion

Keytruda is a powerful medication that has shown significant promise in the treatment of various types of cancer. While it can cause side effects, many of these side effects are manageable and temporary. However, it is essential for patients to be aware of the potential long-term side effects of Keytruda and to work closely with their healthcare provider to monitor their condition and manage any side effects that may arise.

FAQs

1. What is the most common long-term side effect of Keytruda?

The most common long-term side effect of Keytruda is immune-related adverse reactions, including hypophysitis, thyroiditis, adrenal insufficiency, and type 1 diabetes mellitus.

2. Can long-term side effects of Keytruda be managed?

Yes, long-term side effects of Keytruda can often be managed with medication and lifestyle changes. Patients should work closely with their healthcare provider to monitor their condition and adjust their treatment plan as needed.

3. What is the risk of developing long-term side effects with Keytruda?

The risk of developing long-term side effects with Keytruda varies depending on the individual patient and their specific treatment plan. However, according to the FDA, the risk of developing long-term side effects is higher in patients who receive high doses of Keytruda or who have a history of autoimmune disorders.

4. Can Keytruda cause permanent damage?

While Keytruda can cause long-term side effects, it is unlikely to cause permanent damage. However, patients should work closely with their healthcare provider to monitor their condition and adjust their treatment plan as needed to minimize the risk of long-term side effects.

5. Is Keytruda safe for long-term use?

Keytruda is generally considered safe for long-term use when used as directed and under the supervision of a healthcare provider. However, patients should be aware of the potential long-term side effects of Keytruda and work closely with their healthcare provider to monitor their condition and adjust their treatment plan as needed.

Cited Sources:

1. FDA. (2020). Pembrolizumab (Keytruda) Prescribing Information.
2. DrugPatentWatch.com. (2020). Pembrolizumab (Keytruda) Patent Expiration.
3. National Cancer Institute. (2020). Pembrolizumab (Keytruda) Fact Sheet.
4. American Cancer Society. (2020). Pembrolizumab (Keytruda) Side Effects.
5.

“Pembrolizumab (Keytruda) is a monoclonal antibody that targets the PD-1 receptor on T cells, allowing them to recognize and attack cancer cells more effectively.” - National Cancer Institute