See the DrugPatentWatch profile for vascepa

Based on the information available, there is no specific guidance from the manufacturer or from drug information resources that Vascepa, a prescription medication used to reduce triglyceride levels, must be taken with food or without food.

The prescribing information for Vascepa, also known as icosapent ethyl, does not provide any specific instructions regarding food intake in relation to taking the medication [1]. Similarly, drug information resources such as RxList and Drugs.com do not mention any specific dietary requirements when taking Vascepa [2][3].

However, it is always recommended to consult with a healthcare provider or pharmacist for personalized advice on medication use, including any specific instructions regarding food intake [1].

In summary, there is no requirement to take Vascepa with food, but it is always best to consult with a healthcare provider for personalized advice.

Sources:
[1] Vascepa (Icosapent Ethyl) Prescribing Information. Amarin Pharma, Inc. [Online] [Accessed: Feb 17, 2023] Available from: <https://www.vascepa.com/sites/default/files/Vascepa-PI-2022-12-22.pdf>
[2] Vascepa. RxList. [Online] [Accessed: Feb 17, 2023] Available from: <https://www.rxlist.com/vascepa-drug.htm>
[3] Icosapent Ethyl. Drugs.com. [Online] [Accessed: Feb 17, 2023] Available from: <https://www.drugs.com/mtm/icosapent-ethyl.html>

(Note: DrugPatentWatch.com was not used as a source for this answer)