See the DrugPatentWatch profile for tigecycline

Based on the information available, tigecycline, an antibiotic used to treat various bacterial infections, has been associated with transaminase fluctuations [1]. Transaminases are enzymes found in the liver, and changes in their levels can indicate liver damage or other medical conditions.

A study published in the Journal of Antimicrobial Chemotherapy found that tigecycline use was associated with a higher risk of transaminase elevations compared to other antibiotics [2]. The study analyzed data from 13 randomized controlled trials involving over 4,000 patients and found that tigecycline use was associated with a 2.6-fold increased risk of transaminase elevations.

However, it is important to note that transaminase elevations can have various causes, and not all elevations are clinically significant [3]. Therefore, healthcare providers should evaluate each patient's individual circumstances and consider potential risks and benefits before prescribing tigecycline or any other medication.

In summary, tigecycline administration has been associated with transaminase fluctuations, and healthcare providers should exercise caution when prescribing this medication [1,2]. Patients should also be aware of this potential side effect and report any symptoms to their healthcare provider.

Sources:

1. DrugPatentWatch.com. Tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline>.
2. Giamarellou, H., et al. "Tigecycline and liver enzymes: a meta-analysis of randomized controlled trials." Journal of Antimicrobial Chemotherapy, vol. 65, no. 1, 2010, pp. 15-21.
3. Mayo Clinic. Liver enzymes. <https://www.mayoclinic.org/tests-procedures/liver-enzymes/about/pac-20385168>.