See the DrugPatentWatch profile for methotrexate

Yes, it is possible for Methotrexate to interact with other drugs and alter their efficacy. Methotrexate is a medication commonly used to treat certain types of cancer, rheumatoid arthritis, and psoriasis. It can interact with various drugs, including antibiotics, antifungals, and nonsteroidal anti-inflammatory drugs (NSAIDs), which can affect its own efficacy or the efficacy of the other drugs.

Methotrexate interacts with other drugs mainly through pharmacokinetic and pharmacodynamic mechanisms. Pharmacokinetic interactions occur when one drug affects the absorption, distribution, metabolism, or excretion of another drug. Pharmacodynamic interactions occur when one drug affects the action of another drug at its site of action.

For example, methotrexate can interact with probenecid, a medication used to treat gout, by increasing methotrexate levels in the blood, which can increase its toxicity and decrease its efficacy. Methotrexate can also interact with NSAIDs, such as ibuprofen and naproxen, by decreasing the renal clearance of methotrexate, leading to increased methotrexate levels and potential toxicity.

In addition, methotrexate can interact with certain antibiotics, such as penicillins, cephalosporins, and tetracyclines, by decreasing the absorption of methotrexate, leading to decreased efficacy. Methotrexate can also interact with antifungal medications, such as fluconazole and itraconazole, by increasing methotrexate levels, leading to increased toxicity and decreased efficacy.

Therefore, it is essential to inform healthcare providers about all medications, supplements, and herbal products being taken when prescribed methotrexate. Regular monitoring of methotrexate levels and potential toxicity is also necessary when taking methotrexate with other medications.

Sources:

1. DrugPatentWatch.com. (n.d.). Methotrexate. Retrieved from <https://www.drugpatentwatch.com/drugs/methotrexate>
2. Mayo Clinic. (2021). Methotrexate (Oral Route, Injection Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route-injection-route/precautions/drg-20063031>
3. National Library of Medicine. (2021). Methotrexate. Retrieved from <https://medlineplus.gov/druginfo/meds/a68/1305.html>
4. UpToDate. (2021). Methotrexate: Drug Information. Retrieved from <https://www.uptodate.com/contents/methotrexate-drug-information>