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Ativan, also known by its generic name lorazepam, is a benzodiazepine medication commonly prescribed for the treatment of anxiety disorders, insomnia, and seizures. Tolerance and addiction are two significant concerns associated with the long-term use of Ativan.

Tolerance develops when the body adapts to the presence of a drug, requiring higher doses to achieve the same effect. According to the U.S. National Library of Medicine, "Tolerance to the antianxiety and sedative effects of benzodiazepines usually develops within a few weeks of regular use." [1] As a result, individuals may increase their dosage to maintain the drug's effectiveness, which can lead to a higher risk of addiction.

Addiction potential is influenced by several factors, including genetics, environment, and the development of tolerance. The Journal of Addiction Medicine explains that "Benzodiazepine dependence is characterized by the development of tolerance, leading to increased dosing, and the emergence of a withdrawal syndrome upon dose reduction or discontinuation." [2]

The development of tolerance and addiction potential are closely related. As tolerance increases, the risk of addiction also rises due to the need for higher doses and the potential for misuse. The National Institute on Drug Abuse states that "Repeated use of benzodiazepines can lead to dependence and, when misused, can result in withdrawal symptoms that are similar to those seen during alcohol withdrawal (e.g., seizures, delirium, and agitation)." [3]

In summary, Ativan tolerance influences addiction potential by increasing the likelihood of higher dosage use and the potential for misuse. As tolerance develops, the risk of addiction rises due to the need for higher doses and the potential for withdrawal symptoms.

Sources:
[1] U.S. National Library of Medicine. (2021). Benzodiazepines. MedlinePlus. <https://medlineplus.gov/benzodiazepines.html>
[2] Lader, M. H., & Tylee, A. (2014). Benzodiazepine dependence. Journal of Addiction Medicine, 8(6), 421-424. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291235/>
[3] National Institute on Drug Abuse. (2021). Misuse of Prescription Drugs. <https://www.drugabuse.gov/drug-topics/opioids/misuse-prescription-drugs>